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You should avoid taking an antacid within 2 hours before or after you take neurontin, because antacids may make it harder for your body to properly absorb neurontin.

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Patients should be carefully observed for signs of central nervous system cns depression, such as somnolence and sedation, when neurontin is used with other drugs with sedative properties because of potential synergy.

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The pain relieving action of neurontin is believed to be caused by voltage sensitive calcium ion channels.

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coadministration of neurontin 125 to 500 mg; n 48 decreases hydrocodone 10 mg; n 50 cmax and auc values in a dose-dependent manner relative to administration of hydrocodone alone; cmax and auc values are 3 to 4 lower, respectively, after administration of 125 mg neurontin and 21 to 22 lower, respectively, after administration of 500 mg neurontin.

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